Kaare Christensen, MD, PhD, DMSc | |
| | Address: | Epidemiology | | J. B. Winsløws Vej 9B | | 5000 Odense C | | Denmark | | | | | Tel.: | +45 6550 3049 | | Alt. Tel.: | +45 6550 3029 | | Fax: | +45 6550 3682 | | Email: | kchristensen@health.sdu.dk |
|
|
| DMSc, University of Southern Denmark, 1999.
PhD, Odense University, 1994.
MD, Odense University, 1987. |
| Professor of Epidemiology, Institute of Public Health, University of Southern Denmark 2002-
Senior Research Scientist, Sanford
Institute, Duke University, NC, USA 1999- Link here
Director of The Danish Twin Registry 2007-.Link here
Director of the Danish Aging Research Center
Member of the steering committee for the NIA- LLFS Long Life Family Study, National Institutes of Health, National Institute on Aging, USA, 2004- Link here
Member of the steering committee for Genetics of Healthy Aging (GEHA) (EU-funded aging project), 2004- Link here
Work package leader of the project LifeSpan Network, 2007-.Link her
Participant at the EU-sponsored project SHARE.Link here
Research Professor, Institute of Public Health, Odense University, 1998-2002.
Associate Professor, Center for Health and Social Policy, Odense University, Denmark, 1996-98
Assistant Professor, Odense
University, Faculty of Health Science and The Danish Epidemiology
Science Center, Aarhus University 1994-96.
Research fellow, Odense University,
Faculty of Health Sciences 1990-94.
Physician at Fredericia and
Svendborg Hospitals 1987-90.
|
| Genetic-epidemiology, twin
studies, aging, age-related diseases, reproduction, fertility,
congenital malformations, cleft lip and palate, fetal
programming.
See also: Longitudinal
Study of Aging Danish Twins
HONORS AND AWARDS
1993 Winner of the "Scholarship contest of the 7th International Congress on Cleft Palate
and Related Cranio-Facial Anomalies", Broadbeach, Queensland, Australia.
1998 Yde’s Award, Desireé and Niels Yde Foundation.
1999 William Nielsen’s Award, William Nielsen Foundation.
2000 LLG Award 2000, Landsforeningen Læbe-ganespalte (The National Society for Cleft
Lip and Palate).
2004 Research award granted by the Independent Order of Odd Fellows in Odense, Denmark.
2005 University of Southern Denmark first Outreach Award (award for widespread and creative communication of science)
2006 Codan Merit Award for his research achievements within the field of epidemiology
2006 On behalf of the Danish Twin Registry recipient of the ethical merit award for outstanding ethical conduct of health research, granted by the Danish National Committee on Biomedical Research Ethics.
2008 The Erhoff Award for internationally acknowledged medical research. |
| 2009.
| Sørensen M, Christensen K, Stevnsner T, Christiansen L. The Mn-superoxide dismutase single nucleotide polymorphism rs4880 and the glutathione peroxidase 1 single nucleotide polymorphism rs1050450 are associated with aging and longevity in the oldest old. Mechanisms of Ageing and Development 2009;130:308–314.
| Christophersen IE, Ravn LS, Jørgensen EB, Skytthe, Haunsø S, Svendsen JH, Christensen K. Familial aggregation of atrial fibrillation- a study in Danish twins. Circulation Arrhythmia Electrophysiology 2009 DOI: 10.1161/CIRCEP.108.786665 (epub ahead of print).
| Jugessur A, Shi M, Gjessing HK, Lie RT, Wilcox AJ, Weinberg CR, Christensen K, Boyles AL, Daack-Hirsch S, Trung TN, Bille C, Lidral AC, Murray JC. Genetic determinants of facial clefting: Analysis of 357 candidate genes using two national cleft studies from Scandinavia. PloS ONE 2009;4:4:e5385.  Pubmed abstract
| Johnson W, Deary IJ, McGue M, Christensen K. Genetic and environmental transactions linking cognitive ability, physical fitness, and education in late life. Psychology and Aging 2009;24(1):48-62. Pubmed abstract
| Boyles AL, Wilcox AJ, Taylor JA, Shi M, Weinberg CR, Meyer K, Fredriksen A, Ueland PM, Johansen AM, Drevon CA, Jugessur A, Trung TN, Gjessing HK, Vollset SE, Murray JC, Christensen K, Lie RT. Oral facial clefts and gene polymorphisms in metabolism of folate/one-carbon and vitamin A: a pathway-wide association study. Genetic Epidemiology 2009;33(3):247-55 Pubmed abstract
| McEvoy BP, Montgomery GW, McRae AF, Ripatti S, Perola M, Spector TD, Cherkas L, Ahmadi KR, Boomsma D, Willemsen G, Hottenga JJ, Peterson NL, Magnusson PK, Ohm Kyvik K, Christensen K, Kaprio J, Heikkila K, Palotie A, Widen E, Muilu J,Syvanen AC, Liljedahl. Geographical structure and differential natural selection amongst North European populations. Genome Research 2009 (epub ahead of print). Pubmed abstract
| Osler M, Madsen M, Nybo Andersen AM, Avlund K, McGue M, Jeune B, Christensen K. Do childhood and adult socioeconomic circumstances influence health and physicalfunction in middle-age? Social Science and Medicine 2009 (epub ahead of print). Pubmed abstract
| Brønnum-Hansen H, Petersen I, Jeune B, Christensen K. Lifetime according to health status among the oldest olds in Denmark. Age and Ageing 2009;38(1):47-51. Pubmed abstract
| Shi M, Mostowska A, Jugessur A, Johnson MK, Mansilla MA, Christensen K, Lie RT, Wilcox AJ, Murray JC. Identification of microdeletions in candidate genes for cleft lip and/or palate. Birth Defects Research, Part A, Clinical and Molecular Teratology 2009 ;85(1):42-51. Pubmed abstract
| Kulminski AM, Arbeev KG, Culminskaya IV, Ukraintseva SV, Christensen K, Yashin AI. Health-related phenotypes and longevity in danish twins. The Journals of Gerontology, Series A, Biological Sciences and Medical Sciences 2009;64(1):1-8. Pubmed abstract
| Johnson W, Deary IJ, McGue M, Christensen K. Genetic and environmental links between cognitive and physical functions in old age. The Journals of Gerontology, Series B, Psychological Sciences and Social Sciences 2009;64(1):65-72. Pubmed abstract
| 2008.
| Christensen K, McGue M, Petersen I, Jeune B, Vaupel JW. Exceptional longevity does not result in excessive levels of disability. Proceedings of the National Academy of Sciences 2008;105(36):13274-9. Pubmed abstract
| Christensen K, McGue M. Academic achievement in twins. British Medical Journal 2008; 337:a651 (editorial). Pubmed abstract
| Christensen K. Some challenges and possibilities for aging research. Demographic Research 2008 ;19:1575-1586.
| Kimura M, Hjelmborg JvB, Gardner JP, Bathum L, Brimacombe M, Lu X, Christiansen L, Vaupel JW, Aviv A, Christensen K. Telomere length and mortality: a study of leukocytes in elderly Danish twins. American Journal of Epidemiology 2008;167:799-806. Pubmed abstract
| Tan Q, Zhao JH, Zhang D, Kruse TA, Christensen K. Power for genetic association study of human longevity using the case-control design. American Journal of Epidemiology 2008;168(8):890-6. Pubmed abstract
| Tan Q, Zhao J, Li S, Christiansen L, Kruse TA, Christensen K. Differential and correlation analyses of microarray gene expression data in the CEPH Utah families. Genomics 2008; 92(2):94-100. Pubmed abstract
| Christiansen L, Tan Q, Kruse TA, McGue M, Christensen K. Candidate region linkage analysis in twins discordant or concordant for depression symptomatology. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 2008 (epub ahead of print). Pubmed abstract
| Rahimov F, Marazita ML, Visel A, Cooper ME, Hitchler MJ, Rubini M, Doman FE, Govil M, Christensen K, Bille C, Melbye M, Jugessur A, Lie RT, Wilcox AJ, Fitzpatrick DR, Green ED, NISC Comparative Sequencing Program, Mossey PA, Little J, Steegers-Theunissen. Disruption of an AP-2alpha binding site in an IRF6 enhancer is associated with cleft lip. Nature Genetics 2008; 40(11):1341-7. Pubmed abstract
| Jacobsen R, Oksuzyan A, Engberg H, Jeune B, Vaupel JW, Christensen K. Sex differential in mortality trends of old-aged Danes: a nation wide study of age, period and cohort effects. European Journal of Epidemiology 2008 (epub ahead of print). Pubmed abstract
| Christensen K. Den danske middellevetid – hvad gør vi? Ugeskrift for Læger 2008;170(33):2421 (scientific editorial in Danish)
| Engberg H, Christensen K, Andersen-Ranberg K, Vaupel JW, Jeune B. Improving activities of daily living in Danish centenarians – but only in women: a comparative study of touuuwo birth cohorts born in 1895 and 1905. Journal of Gerontology: Medical Sciences 2008;63A(11):1186-92. Pubmed abstract
| Boyles AL, Wilcox AJ, Taylor JA, Shi M, Weinberg CR, Meyer K, Fredriksen A, Ueland PM, Johansen AM, Drevon CA, Jugessur A, Trung TN, Gjessing HK, Vollset SE, Murray JC, Christensen K, Lie RT. Oral facial clefts and gene polymorphisms in metabolism of folate/one-carbon and vitamin A: a pathway-wide association study. Genetic Epidemiology 2008 (epub ahead of print). Pubmed abstract
| Jensen MS, Toft G, Thulstrup AM, Henriksen TB, Olsen J, Christensen K, Bonde JP. Cryptorchidism concordance in mono- and dizygotic twin brothers, full brothers and half brothers. Fertility and Sterility 2008 (epub ahead of print).
| Jacobsen PK, Sigsgaard T, Pedersen OF, Christensen K, Miller MR. Lung function as a predictor of survival in very elderly people: the Danish 1905 cohort study. Journal of the American Geriatrics Society 2008;56(11):2150-2. Pubmed abstract
| Osler M, McGue M, Lund R, Christensen K. Marital status and twins' health and behavior: an analysis of middle-aged Danish twins. Psychosomatic Medicine 2008; 70(4):482-7. Pubmed abstract
| Gunn DA, Murray PG, Tomlin CC, Rexbye H, Christensen K, Mayes AE. Perceived age as a biomarker of ageing: a clinical methodology. Biogerontology 2008; 9(5):357-64.
| Lorenz D, Papengut F, Frederiksen H, Kopper F, Klebe S, Christensen K, Schreiber S, Deuschl G. Evaluation of a screening instrument for essential tremor. Movement Disorders 2008;23(7):1006-12
| Hartvigsen J, Christensen K. Pain in the back and neck are with us until the end: a nationwide interview-based survey of Danish 100-year-olds. Spine 2008;33(8):909-13. Pubmed abstract
| Engberg H, Christensen K, Andersen-Ranberg K, Jeune B. Cohort changes in cognitive function among Danish centenarians. A comparative study of 2 birth cohorts born in 1895 and 1905. Dementia and Geriatric Cognitive Disorders 2008;26(2):153-160. Pubmed abstract
| Oksuzyan O, Juel K, Vaupel JW, Christensen K. Males: good health and high mortality. Sex differences in health and ageing (Review), Aging Clinical and Experimental Research 2008;20(2):91-102.
| Christensen K, Bathum L, Christiansen L. Biological indicators and genetic information in Danish twin and oldest-old surveys. Biosocial Surveys. National Research Council (eds. Weinstein M, Vaupel JW, Wachter KW), The National Academies Press, Washington, USA, 2008. Pp: 15-41.
| Kimura M, Cherkas LF, Kato BS, Demissie S, Hjelmborg JB, Brimacombe M, Cupples A, Hunkin JC, Gardner JF, Lu X, Cao X, Sastrasinh M, Province MA, Hunt SC, Christensen K, Levy D, Spector TD, Aviv A. Offspring’s leukocyte telomere length, paternal age, and telomere elongation in sperm. PLoS Genetics 2008;4(2):e37. Pubmed abstract
| Hjelmborg J, Fagnani C, Silventoinen K, McGue M, Korkeila M, Christensen K, Rissanen A, Kaprio J. Genetic influences on growth traits of BMI: a longitudinal study of adult twins. Obesity, 2008; 16(4):847-52. Pubmed abstract
| Schnack TH, Zdravkovic S, Myrup C, Westergaard T, Christensen K, Wohlfahrt J, Melbye M. Familial aggregation of hypospadias – a cohort study. American Journal of Epidemiology 2008;167: 251-256. Pubmed abstract
| Juel K, Christensen K. Are men seeking advice too late? Contacts to general practitioners and hospital admissions in Denmark 2005. Journal of Public Health , 2008;30(1):111-3.
| Rodgers, JL,, Kohler H-P, McGue M, Behrman JR, Petersen I, Bingley P, Christensen K. Education and cognitive ability as direct, mediated, or spurious influences on female age at first birth: Behavior genetic models fit to Danish twin data. American Journal of Sociology 2008, 114 Suppl:202–S232 (Special Issue on Genetics and Social Structure).
| Lorenz D, Klebe S, Stevanin G, Thier S, Nebel A, Feingold J, Frederiksen H,. Dopamine receptor D3 gene and essential tremor in large series of German, Danish and French patients. European Journal of Human Genetics 2008 (epub ahead of print). Pubmed abstract
| Christensen K. Den danske middellevetid – hvad gør vi? [The Danish average length of life – what do we do?] Ugeskrift for Laeger 2008;170(33):2421 (scientific editorial (Danish)) Pubmed abstract
| 2007.
| Christensen K, Murray JC. What genome-wide association studies can do for medicine.
New England Journal of Medicine 2007;356(11):1094-1097.
| Christensen K. Ældre. I: Folkesundhedsrapporten, Danmark 2007 (eds. Kjøller M, Juel K, Kamper-Jørgensen F). Statens Institut for Folkesundhed [National Institute of Public Health], University of Southern Denmark. Copenhagen, 2007:413-424.
| Christensen K. Forskelle mellem mænd og kvinder. I: Folkesundhedsrapporten, Danmark 2007 (eds. Kjøller M, Juel K, Kamper-Jørgensen F). Statens Institut for Folkesundhed [National Institute of Public Health], University of Southern Denmark. Copenhagen, 2007: 425-432.
| Bathum L, Hjelmborg J, Christiansen L, McGue M, Jeune B, Christensen K. Methylenetetrahydrofolate Reductase 677C>T and Methionine Synthase 2756A>G Mutations: No Impact on Survival, Cognitive Functioning, or Cognitive Decline in Nonagenarians.The Journals of Gerontology. Series A. Biological Sciences and Medical Sciences 2007;62(2):196-201
Pubmed abstract
| Lamberth JC, Ferreira S, Gussekloo J, Christiansen L, Brysbaert G, Slagboom E, Cottel D, Petit T, Hauw JJ, Dekosky ST, Richard F, Berr C, Lendon C, Kamboh MI, Mann D, Christensen K, Westendorp R, Amouyel P. Evidence for the association of the S100beta gene with low cognitive performance and dementia in the elderly. Molecular Psychiatry 2007 [epub ahead of print]. Pubmed abstract
| Bille C, Olsen J, Vach W, Knudsen VK, Olsen SF, Rasmussen K, Murray JC, Andersen AMN, Christensen K. Oral clefts and life style factors – a case-cohort study based on prospective Danish data. European Journal of Epidemiology 2007;22:173-181. Pubmed abstract
| McGue M, Christensen K. Social activity and healthy aging: a study of aging Danish twins. Twin Research and Human Genetics 2007;10(2):255-65. Pubmed abstract
| Morales-Suárez-Varela MM, Bech BH, Christensen K, Olsen J. Coffee and smoking as risk factors of twin pregnancies: the Danish national birth cohort. Twin Research and Human Genetics 2007;10(4):597-603. Pubmed abstract
| Tan Q, Christiansen L, Brasch-Andersen C, Zhao JH, Li S, Kruse TA, Christensen K. Retrospective analysis of main and interaction effects in genetic association studies of human complex traits. BMC Genetics 2007; 8(1):70. Pubmed abstract
| Perola M, Sammalisto S, Hiekkalinna T, Martin NG, Visscher PM, Montgomery GW, Benyamin B, Harris JR, Boomsma D, Willemsen G, Hottenga JJ, Christensen K, Kyvik KO, Sørensen TI, Pedersen NL, Magnusson PK. ,Spector TD, Widen E, Silventionen K, Kaprio J, Palotie A, Peltonen G, GenomEUtwin Project. Combined genome scans for body stature in 6,602 European twins: evidence for common caucasian Loci. PLoS Genetics 2007;3(6):e97. Pubmed abstract
| Christiansen L, Tan Q, Iachina M, Bathum L, Kruse TA, McGue M, Christensen K. Candidate gene polymorphisms in the serotonergic pathway: influence on depression symptomatology in an elderly population. Biological Psychiatry 2007; 61(2): 223-230. Pubmed abstract
| Shi M, Christensen K, Weinberg CR, Romitti P, Bathum L, Lozada A, Morris RW, Lovett M, Murray JC. Orofacial cleft is increased with maternal smoking and specific detoxification-gene variants. American Journal of Human Genetics 2007;80(1):76-90. Pubmed abstract
| Krarup-Andersen F, Christensen K, Frederiksen H. Self-related health and age. A cross-sectional and longitudinal study of 11,000 Danes aged 45-102. Scandinavian Journal of Public Health 2007;35(2):164-171. Pubmed abstract
| de Maat MPM, Madsen JS, Langdahl B , Bladbjerg EM, Tofteng CL ,Abrahamsen B , Rejnmark L, Brixen K, Christensen K, Jespersen J, Kristensen SR. Genetic variation in estrogen receptor, C-reactive protein and fibrinogen does not predict the plasma levels of inflammation markers after longterm hormone replacement therapy. Journal of Thrombosis and Haemostasis 2007; 97: 234–239. Pubmed abstract
| Franceschi C, Bezrukov V, Blanché H, Bolund L, Christensen K, et al. Genetics of healthy aging in Europe: the EU-integrated project GEHA (GEnetics of Healthy Aging). Annals of the New York Academy of Sciences 2007;1100:21-45. Pubmed abstract
| Zhu JL, Basso O, Obel C, Christensen K, Olsen J. Infertility, infertility treatment and twinning: the Danish National Birth Cohort. Human Reproduction 2007;4:1086-1090. Pubmed abstract
| Sørensen GL, Petersen I, Thiel S. Fenger M, Christensen K, Kyvik KO, Sørensen TI, Holmskov U, Jensenius JC. Genetic influences on mannan-binding lectin (MBL) and mannan-binding lectin associated serine protease-2 (MASP-2). Genetic Epidemiology 2007;31(1):31-41. Pubmed abstract
| Hartvigsen J, Christensen K. Active lifestyle protects against incident low back pain in seniors. A population-based 2-year prospective study of 1387 Danish twins aged 70-100 years. Spine 2007;32(1):76-81.
| Osler M, McGue M, Christensen K. Socioeconomic position and twins’ health: a life-course analysis of 1266 pairs of middle-aged Danish twins. International Journal of Epidemiology 2007;36(1):77-83.
| 2006.
| Christensen K, Johnson TE, Vaupel JW. The quest for genetic determinants of human longevity: challenges and insights. Nature Reviews Genetics 2006;7:436-448. Pubmed abstract
| Christensen K, Petersen I, Skytthe A, Herskind AM, McGue M, Bingley P. Comparison of academic performance of twins and singletons in adolescence: a follow-up study. British Medical Journal 2006;333(7578):1095. Link.
| Christensen K, Herskind AM, Vaupel JW.
Why Danes are smug: comparative study of life satisfaction in the European Union. British Medical Journal 2006;333:1289-91.  Pubmed abstract
Skytthe A, Kyvik K, Bathum L, Holm N, Vaupel JW, Christensen K. The Danish Twin Registry in the New Millennium. Twin Research and Human Genetics 2006;9(6):763-771.
Avila JR, Jezewski PA, Vieira AR, Orioli IM, Castilla EE, Christensen K, Daack-Hirsch S, Romitti PA, Murray JC PVRL1 variants contribute to non-syndromic cleft lip and palate in multiple populations. American Journal of Medical Genetics Part A 2006; 1;140(23):2562-70. Pubmed abstract
Tan Q, Kruse TA, Christensen K. Design and analysis in genetic studies of human ageing and longevity.Ageing Research Reviews 2006; 5(4): 371-387.
Pubmed abstract
| Jensen TK, Joffe M, Scheike T, Skytthe A, Gaist D, Petersen I, Christensen, K. Early exposure to smoking and future fecundity among Danish twins. International Journal of Andrology 2006; 29 (6): 603-613 Pubmed abstract
| Hjelmborg J vB, Iachine I, Skytthe A, Vaupel JW, McGue M, Koskenvuo M, Kaprio J, Pedersen NL, Christensen K. Genetic influence on human lifespan and longevity.Human Genetics 2006;119(3):312-321.
Pubmed abstract
| Frederiksen H, Hjelmborg J, Mortensen J, McGue M, Vaupel JW, Christensen K. Age trajectories of grip strength: cross-sectional and longitudinal data among 8,342 Danes aged 46 to 102. Annals of Epidemiology 2006;16(7):554-62. Pubmed abstract
| Warrington A, Vieira AR, Christensen K, Orioli IM, Castilla EE, Romitti PA, Murray JC. Genetic evidence for the role of loci at 19q13 in cleft lip and palate. Journal of Medical Genetics 2006;43(6):e26. Pubmed abstract
| Storgaard L, Bonde JP, Ernst E, Andersen CY, Spano M, Christensen K, Petersen HC, Olsen J. Genetic and environmental correlates of semen quality: a twin study. Epidemiology 2006;17(6):674-681. Pubmed abstract
| Bischoff C, Petersen HC, Graakjaer J, Andersen-Ranberg K, Vaupel JW, Bohr VA, Kølvraa S, Christensen K. No association between telomere length and survival among the elderly and oldest-old. Epidemiology 2006;17(2):190-194. Pubmed abstract
| Christiansen L, Brasch-Andersen C, Bathum L, Kruse TA, Christensen K. A longitudinal study of the effect of GSTT1 and GSTM1 gene copy number on survival. Mechanisms of Ageing and Development 2006;127(7):597-599. Pubmed abstract
| Tomassini C, Grundy E, Skytthe A, Christensen K. Twins and their health cost: consequences of multiple births on parental health and mortality in Denmark and England and Wales. Twin Research and Human Genetics 2006;9(3):444-449. Pubmed abstract
| Hartvigsen J, Frederiksen H, Christensen K. Physical and mental function and incident low back pain in seniors. A population-based two-year prospective study of 1387 Danish twins aged 70 to 100 years. Spine 2006;31(14):1628-1632. Pubmed abstract
| Graakjaer J, Londono-Vallejo JA, Christensen K, Kolvraa. The pattern of chromosome-specific variations in telomere length in humans shows sign of heritability and is maintained through life. Annals of the New York Academy of Sciences 2006;1067:311-6. Pubmed abstract
| Sild M, Koca C, Bendixen MH, Frederiksen H, McGue M, Kolvraa S, Christensen K, Nexo B. Possible associations between successful aging and polymorphic markers in the Werner gene region. Annals of the New York Academy of Sciences 2006;1067:309-10. Pubmed abstract
| Singh R, Kolvraa S, Bross P, Christensen K, Gregersen N, Tan Q, Jensen UB, Eiberg H, Rattan SI. Heat-schock protein 70 genes and human longevity: a view from Denmark. Annals of the New York Academy of Sciences 2006;1067:301-8. Pubmed abstract
| Christiansen L, Tan Q, Iachina M, Bathum L, Kruse TA, McGue M, Christensen K. Candidate gene polymorphisms in the serotonergic pathway: influence on depression symptomatology in an elderly population. Biological Psychiatry 2006 [epub ahead of print] Pubmed abstract
| Rexbye H, Petersen I, Johansen M, Klitkou L, Jeune B, Christensen K. Influence of environmental factors on facial ageing. Age and Ageing 2006;35:110-115. Pubmed abstract
| Bladbjerg EM, de Maat MPM, Christensen K, Bathum L, Jespersen J, Hjelmborg J. Genetic influence on thrombotic risk markers in the elderly – a Danish twin study. Journal of Thrombosis and Haemostasis Haemost 2006;4:599-607. Pubmed abstract
| Morales-Suarez-Varela MM, Bille C, Christensen K, Olsen J. Smoking habits, nicotine use, and congenital malformations. Obstetricsand Gynecology 2006;107:51-7.
| Tan Q, Christiansen L, Bathum L, Li S, Kruse TA, Christensen K. Genetic associations analysis of human longevity in cohort studies of elderly subjects: an example of PON1 gene in the Danish 1905 birth cohort. Genetics 2006;172:1812-1828. Pubmed abstract
| Silventoinen K, Zdravkovic, S, Skytthe A, McCarron P, Herskind AM, Koskenvuo M, de Faire U, Pedersen N, Christensen K, Kaprio J. Association between height and coronary heart disease mortality: a prospective study of 35,000 twin pairs. American Journal of Epidemiology 2006; 163:615-621.
Pubmed abstract
| Kohler H-P, Rodgers JL, Miller WB, Skytthe A, Christensen K. Bio-social determinants of fertility. Int J Antrol 2006;29:46-53.
Pubmed abstract
| Book.
Christensen K, Graugaard C, Bonde H, Helge JW, Madsen SAa. Kend din krop, mand. Aschehoug, Copenhagen, 2006 (chapter on men’s health: pages 14-87).
Here
| 2005.
| Bischoff C, Graakjaer J, Petersen HC, Jeune B, Bohr VA, Koelvraa S, Christensen K. Telomere length among the elderly and oldest-old. Twin Research and Human Genetics 2005;8(5):425-432.
Pubmed abstract
| Bischoff C, Graakjaer J, Petersen HC, Hjelmborg JvB, Vaupel JW, Bohr VA, Koelvraa S, Christensen K. The heritability of telomere length among the elderly and oldest-old. Twin Research and Human Genetics 2005;8(5):433-439.
Pubmed abstract
| Malis C, Rasmussen EL, Poulsen P, Petersen I, Christensen K, Beck-Nielsen H, Astrup A, Vaag AA. Total and regional fat distribution is strongly influenced by genetic factors in young and elderly twins. Obesity Research 2005;13(12):2139-45. Pubmed abstract
| Rasulo D, Christensen K, Tomassini C. The influence of social relations on mortality in later life: a study on elderly Danish twins. The Gerontologist 2005;45(5):601-8.
Pubmed abstract
| Tveskov C, Skytthe A, Arnsbo P, Vaupel JW, Moller M, Christensen K. Twins with implanted pacemakers: Is there an increased mortality risk for the co-twin? A follow-up study based on the Danish Twin Registry and the Danish Pacemaker Register. Europace 2005; 7(6): 598-603.
Pubmed abstract
| Rohr G, Stovring H, Christensen K, Gaist D, Nybo H, Kragstrup J. Characteristics of middle-aged and elderly women with urinary incontinence. Scand J Prim Health Care 2005;23(4):203-8.
Pubmed abstract
| Bathum L, Christiansen L, Tan Q, Vaupel J, Jeune B, Christensen K. No evidence for an association between extreme longevity and Microsomal Transfer Protein polymorphisms in a longitudinal study of 1651 nonagenarians. Eur J Hum Genet2005;13(10):1154-8
Pubmed abstract
| Rexbye H, Petersen I, Iachina M, Mortensen J, McGue M, Vaupel JW, Christensen K. Hair loss among elderly men: etiology and impact on perceived age. Journal of Gerontology: Medical Sciences 2005;60A(8):1077-82.
Pubmed abstract
| Herskind AM, Basso O, Olsen J, Skytthe A, Christensen K. Is natural twinning rate still declining? Epidemiology 2005; 16(4):591 (Letter). Pubmed abstract
| Etheredge AJ, Christensen K, Del Junco D, Murray JC, Mitchell LE. Evaluation of two methods for assessing gene-environment interactions using data from the Danish case-control study of facial clefts. Birth Defects Research part A: Clinical and Molecular Teratology 2005;73(8):541-6.
Pubmed abstract
| Basso O, Nohr EA, Olsen J, Christensen K. Relationship of maternal body mass index and height to twinning. Obstetrics and Gynecology 2005;106(2):411 (comment/letter).
Pubmed abstract
| Aviv A, Shay J, Christensen K, Wright W. The longevity gender gap: are telomeres the explanation? Sci Aging Knowledge Environ 2005;23:pe16.
Pubmed abstract
| Bille C, Winter JF, Bautz A. Murray JC, Olsen J, Christensen K. Cancer risk in persons with oral cleft – a population-based study of 8,093 cases. American Journal of Epidemiology 2005;161(11):1047-55.
Pubmed abstract
| Tan Q, Christiansen L, Bathum L, Zhao JH, Yashin AI, Vaupel JW, Christensen K, Kruse TA. Estimating haplotype relative risks on human survival in population-based association studies. Human Heredity 2005;59:88-97.
Pubmed abstract
| Bille C, Skytthe A, Vach W, Knudsen LB, Andersen A-MN, Murray JC, Christensen K. Parent’s age and the risk of oral clefts. Epidemiology 2005;16(3):311-316.
Pubmed abstract
| Bille C, Knudsen LB, Christensen K. Changing lifestyles and oral clefts occurrence in Denmark. Cleft Palate-Craniofacial Journal 2005;42(3):255-59.
Pubmed abstract
| Kristiansen M. Knudsen GP, Bathum L, Naumova AK, Sørensen TI, Brix TH, Svendsen AJ, Christensen K, Kyvik KO, Ørstavik KH. Twin study of genetic and aging effects on X chromosome inactivation. European Journal of Human Genetics 2005; 13(5):599-606.
Pubmed abstract
| Tan Q, Christensen K, Christiansen L, Frederiksen H, Bathum L, Dahlgaard J, Kruse TA. Genetic dissection of gene expression observed in whole blood samples of elderly Danish twins. Human Genetics 2005;117:267-274.
Pubmed abstract
| Kjeldsen MJ, Corey LA, Solaas MH, Friis ML, Harris JR, Kyvik KO, Christensen K, Pellock JM. Genetic factors in seizures: a population-based study of 47,626 US, Norwegian and Danish twin pairs. Twin Research and Human Genetics 2005;8(2):138-147.
Pubmed abstract
| Gaist D, Pedersen L, Madsen C. Tsiropoulos I, Bak S. Sindrup S, McGue M, Rasmussen BK, Christensen K. Long-term effects of migraine on cognitive function. A population-based study of Danish twins. Neurology 2005;64:600-607.
Pubmed abstract
| Mansilla MA, Kimani, Mitchell LE, Christensen K. et al. Discordant MZ twins with cleft lip and palate: a model for identifying genes in complex traits. Twin Research and Human Genetics 2005;8(1):39-46.
| Wienke A, Herskind AM, Christensen K, Skytthe A, Yashin AI. The heritability of CHD mortality in Danish twins after controlling for smoking and BMI. Twin Research and Human Genetics 2005;8(1):53-59.
| Poulsen P, Levin K, Petersen I, Christensen K, Beck-Nielsen H, Vaag A. Heritability of insulin secretion, peripheral and hepatic insulin action, and intracellular glucose partitioning in young and old Danish twins. Diabetes 2005;54(1):275-83. Pubmed abstract
| Kristiansen M, Knudsen GP, Bathum L, Naumova AK, Sørensen TI, Brix TH, Svendsen AJ, Christensen K, Kyvik KO, Ørstavik KH. Twin study of genetic and aging effects on X chromosome inactivation. Eur J Hum Genet 2005;13(5):599-606.
Pubmed abstract
| Brakefield PM, Gems D, Cowen T, Christensen K et al. What are the effects of maternal and pre-adult environments on ageing in humans, and are there lessons from animal models? Mech ageing Dev. 2005;126:431-438. Pubmed abstract
| Hartvigsen J, Pedersen H C, Frederiksen H, Christensen K. Small effects of genetic factors on neck pain in old age. A study of 2,108 Danish twins 70 years of age and older.Spine 2005;30(2):206-208.
| Jensen TK, Joffe M, Scheike T, Skytthe A, Gaist D, Christensen K. Time trends in waiting time to pregnancy among Danish twins.Human Reproduction2005;20(4):955-964.
Pubmed abstract
| 2004.
| Tan Q. Christiansen L, Bathum L, Zhao JH, Vach W, Vaupel JW, Christensen K, Kruse TA. Haplotype effects on human survival: logistic regression models applied to unphased genotype data.Annals of Human Genetics 2004;68:168-175 Pubmed abstract
| Zucchero TM et al. Interferon regulatory factor 6 (IRF6) gene variants and the risk of isolated cleft lip or palate.
N Engl J Med. 2004 Aug 19;351(8):769-80. Pubmed abstract
| Christensen K, Juel K, Herskind AM, Murray JC. Long term follow up study of survival associated with cleft lip and palate at birth. BMJ 2004;328(7453):1405. Pubmed abstract
| Basso O, Nohr EA, Christensen K, Olsen J. Risk of Twinning as a Function of Maternal Height and Body Mass Index
. JAMA.2004; 291: 1564-1566.
Pubmed abstract
| De Maat MPM, Bladbjerg EM, Hjelmborg JvB, Bathum L, Jespersen J, Christensen K. Genetic influence on inflammation variables in the elderly. Arterioscler Thromb Vasc Biol 2004;24:2168-2173. Pubmed abstract
| Christiansen L, Bathum L. Frederiksen H, Christensen K. Paraoxonase 1 polymorphisms and survival. European Journal of Human Genetics2004;12(10):843-47. Pubmed abstract
| Bathum L, Fagnani C, Christiansen L, Christensen K. Heritability of biochemical kidney markers and relation to survival in the elderly – results from a Danish population-based twin study. Clinica Chimica Acta 2004;349:143-150. Pubmed abstract
| Rohr G, Christensen K, Ulstrup K, Kragstrup J. Reproducibility and validity of simple questions to identify urinary incontinence in elderly women. Acta Obstet Gynecol Scand 2004; 83: 969-72. Pubmed abstract
| Rohr G, Kragstrup J, Gaist D, Christensen K. Genetic and environmental influences on urinary incontinence: a Danish population-based twin study of middle-aged and elderly women. Acta Obstet Gynecol Scand 2004; 83: 978-82. Pubmed abstract
| Christiansen L, Petersen HC, Bathum L, Frederiksen H, McGue M, Christensen K. The catalase -262C/T promoter polymorphism and aging phenotypes. J Gerontol A Biol Sci Med Sci 2004;59(9):B886-9. Pubmed abstract
| Bathum L, Hjelmborg J, Christiansen L, Madsen JS, Skytthe A, Christensen K. Evidence for an association of methylene tetrahydrofolate reductase polymorphism C677T and an increased risk of fractures: results from a population-based Danish twin study. Osteoporosis International 2004;15:659-664. Pubmed abstract
| Bendixen MH, Nexø BA, Bohr VA, Frederiksen H, McGue M, Kølvraa S, Christensen K. A polymorphic marker in the first intron of the Werner gene associates with cognitive function in aged Danish twins. Experimental Gerontology 2004;39:1101-1107. Pubmed abstract
| Tan Q, Christiansen L, Christensen K, Kruse TA, Bathum L. Apolipoprotein E genotype frequency patterns in aged Danes as revealed by logistic regression models. European Journal of Epidemiology 2004;19:651-656. Pubmed abstract
| Tan Q, Yashin AI, Christensen K, Jeune B, De Benedictis G, Kruse TA, Vaupel JW. Multidisciplinary approaches in genetic studies of human aging and longevity. Current Genomics 2004;5:409-416.
| Singh R, Kølvraa S, Bross P, Gregersen N, Andersen Nexø B, Frederiksen H, Christensen K, Rattan SIS. Association between low self-rated health and heterozygosity for -110A>C polymorphism in the promoter region of HSP70-1 in aged Danish twins. Biogerontology 2004;5:169-176. Pubmed abstract
| Graakjaer J, Pascoe L, Der-Sarkissian H, Thomas G, Kølvraa S, Christensen K, Londoño-Vallejo J-A. The relative lengths of individual telomeres are defined in the zygote and strictly maintained during life. Aging Cell 2004;3:97-102. Pubmed abstract
| Christiansen L, Bathum L, Andersen-Ranberg K, Jeune B, Christensen K. Modest implication of interleukin-6 promoter polymorphisms in longevity. Mech Ageing Dev. 2004;125(5):391-5. Pubmed abstract
| Christensen K, Iachina I, Rexbye H, Tomassini C, Frederiksen H, McGue M, Vaupel JW. Looking old for your age: Genetics and mortality. Epidemiology 2004;15:251-252.
| Hartvigsen J, Christensen K, Frederiksen H, Pedersen HC. Genetic and environmental contributions to back pain in old age. A study of 2, 108 Danish Twins aged 70 and older. Spine 2004;29(8):897-902. Pubmed abstract
| Tan Q, De Benedictis G, Yashin AI, Bathum L, Christiansen L, Dahlgaard J, Frizner N, Vach W, Vaupel JW, Christensen K, Kruse TA. Assessing genetic association with human survival at multi-allelic loci. Biogerontology 2004;4:89-97.
| Laursen M, Bille C, Olesen AW, Hjelmborg J, Skytthe A, Christensen K. Genetic influence on prolonged gestation: A population-based Danish twin study. American Journal of Obstetrics and Gynecology 2004;190:489-94.
Pubmed abstract
| Shi M, Caprau D, Dagle J, Christiansen L, Christensen K, Murray JC. Application of kinetic polymerase chain reaction and molecular beacon assays to pooled analyses and high-throughput genotyping for candidate genes. Birth Defects Research 2004;(Part A)70:65-74. Pubmed abstract
| Tan Q, Zhao JH, Hjelmborg J, Vach W, Vaupel JW, Christensen K, Kruse TA. Power of non-parametric linkage analysis in mapping genes contributing to human longevity in long-lived sib-pairs. Genetic Epidemiology 2004;26:245-253. Pubmed abstract
| Lorenz D, Frederiksen H, Moises H, Kopper F, Deuschl G, Christensen K. High concordance for essential tremor in monozygotic twins of old age. Neurology 2004;62(2):208-211. Pubmed abstract
| 2003.
| Vaupel JW, Carey JR, Christensen K. It’s never too late. Science 2003;301:1679-1681. Pubmed abstract
| Tomassini C, Juel K, Holm NV , Skytthe A, Christensen K. Risk of suicide in twins: 51 year follow up study.BMJ 2003;327:373-4. Pubmed abstract
| Wienke A, Holm NV, Christensen K, Skytthe A, Juel K, Vaupel JW, Yashin AI. The heritability of cause-specific mortality: a correlated gamma-frailty model applied to mortality due to respiratory diseases in Danish twins born 1870-1930. Statistics in Medicine 2003;22:3873-3887. Pubmed abstract
| Frederiksen H, Bathum L, Worm C, Christensen K, Puggaard L. ACE genotype and physical training effects: A randomized study among elderly Danes. Aging Clinical and Experimental Research, 2003;15(4):284-291. Pubmed abstract
| Tan Q, Bathum L, Christiansen L, De Benedictis G, Dahlgaard J, Frizner N, Vach W, Vaupel JW, Yashin AI, Christensen K, Kruse TA. Logistic regression models for polymorphic and antagonistic pleiotropic gene action on human aging and longevity. Annals of Human Genetics, 2003;67:598-607. Pubmed abstract
| Hartvigsen J, Christensen K, Frederiksen H. Back pain remains a common symptom in old age. A population-based study of 4486 Danish twins aged 70-102. European Spine Journal, 2003;12:528-534. Pubmed abstract
| Nybo H, Petersen HC, Gaist D, Jeune B, Andersen K, McGue M, Vaupel JW, Christensen K. Predictors of mortality in 2,249 nonagenarians – The Danish 1905-cohort survey. Journal of American Geriatrics Society 2003;51(10):1365-1373.
Pubmed abstract
| Shi M, Caprau D, Romitti P, Christensen K, Murray JC. Genotype frequencies and linkage disequilibrium in the CEPH human diversity panel for variants in folate pathways genes MTHRF, MTHFD, MTRR, RFC1 and GCP2. Birth Defects Research 2003;67:545-549.
| Skytthe A, Pedersen NL, Kaprio J, Stazi MA, Hjelmborg J, Iachine I, Vaupel JW, Christensen K. Longevity studies in GenomEUtwin. Twin Research 2003;6(5):448-454.
Pubmed abstract
| Christiansen L, Frederiksen H, Schousboe K, Skytthe A, von Wurmb Schwark N, Christensen K, Kyvik K. Age- and sex-differences in the validity of questionnaire-based zygosity in twins. Twin Research 2003;6(4):275-8. Pubmed abstract
| Gaist D, Pedersen NL, Koskenvuo M, Bak S, Giampaoli S, Christensen K, Kaprio J. Stroke research in GenomEUtwin. Twin Research 2003;6(5):442-447.
| Jezewski PA, Vieira AR, Nishimura C, Ludwig B, Johnson M, O’Brien SE, Daack-Hirsch S, Schultz RE, Weber A, Nepomucena B, Romitti PA, Christensen K, Orioli IM, Castilla EE, Machida J, Natsume N, Murray JC. Complete sequencing shows a role for MSX1 in non-syndromic cleft lip and palate. Journal of Medical Genetics 2003;40(6):399-407.
Pubmed abstract
| Madsen JS, Kristensen SR, Gram J, Bladbjerg EM, Henriksen FL, Christensen K, Jespersen J. Positive impact of hormone replacement therapy on the fibrinolytic system: a long-term randomized controlled study of healthy postmenopausal women. Journal of Thrombosis and Haemostasis 2003;1(9):1984-1991. Pubmed abstract
| Kjeldsen MJ, Corey LA, Christensen K, Friis ML. Epileptic seizures and syndromes in twins: The importance of genetic factors. Epilepsy Research 2003;55:137-146.
Pubmed abstract
| Mitchell LE, Murray JC, O'Brien S, Christensen K. Retinoic acid receptor Alpha gene variants, multivitamin use and liver intake as risk factors for oral clefts: A Population-based case-control study in Denmark, 1991-1994. American Journal of Epidemiology 2003;158:69-76. Pubmed abstract
| Jakobsen LP, Mølsted K, Christensen K. Occurrence of cleft lip and palate in the Faeroe Islands and Greenland from 1950 to 1999. Cleft Palate-Craniofacial Journal 2003;40(4):426-430. Pubmed abstract
| Graakjaer J, Bischoff C, Korsholm L, Holstebroe S, Vach W, Bohr VA, Christensen K, Kølvraa S. The pattern of chromosome-specific variations in telomere length in humans is determined by inherited, telomere-near factors and is maintained throughout life.Mech Ageing Dev. 2003 May;124(5):629-40. Pubmed abstract
| Larsen TB, Sørensen HT, Skytthe A, Johnsen SP, Vaupel JW, Christensen K. Major genetic susceptibility for venous thromboembolism in men: A study of Danish twins. Epidemiology 2003;14:328-332. Pubmed abstract
| Christensen K, Frederiksen H, Vaupel JW, McGue M. Age trajectories of genetic variance in physical functioning: A longitudinal study of Danish twins aged 70 years and older.Behavior Genetics 2003;33(2):125-135.
| McGue M, Christensen K. The heritability of depression symptoms in elderly Danish twins: Occasion-specific versus general effects. Behavior Genetics 2003;33(2):83-93.
| Bak S, Andersen M, Tsiropoulos I, Rodriguez LAG, Hallas, J, Christensen K, Gaist D. Risk of stroke associated with non-steroidal anti-inflammatory drugs: A nested case-control study. Stroke 2003;34:379-386. Pubmed abstract
| Frederiksen H, Christensen K. The influence of genetic factors on physical functioning and exercise in second half of life. Scand J Med Sci Sports 2003;13(1):9-18. Pubmed abstract
| Frederiksen H, Gaist D, Bathum L, Andersen K, McGue M, Vaupel JW, Christensen K. Angiotensin I – Converting Enzyme (ACE) gene polymorphism in relation to physical performance, cognition and survival. A follow-up study of elderly Danish Twins. Annals of Epidemiology 2003;13(1):57-65. Pubmed abstract
| Christensen K, Kohler HP, Basso O, Olsen J, Vaupel JW, Rodgers JL. The correlation of fecundability among twins: Evidence of a genetic effect on fertility? Epidemiology 2003;14(1):60-64 Pubmed abstract
| 2002.
| Hjøllund NHI, Storgaard L, Ernst E, Bonde JPE, Christensen K, Olsen J. Correlation of scrotal temperature in twins. Human Reproduction 2002;17(7):1837-8. Pubmed abstract
| Johnson W, McGue M, Gaist D, Vaupel JW, Christensen K. Frequency and heritability of depression symptomatology in the second half of life: evidence from Danish twins over 45. Psychological Medicine, 2002; 32(7):1175-85. Pubmed abstract
| McGue M, Christensen K. The heritability of level and rate-of-change in cognitive functioning in Danish twins aged 70 years and older. Experimental Aging Research, 2002;28(4):435-51. Pubmed abstract
| Christensen K. Vitamins, fever and birth defects - consistent interaction or persistent bias? Epidemiology, 2002;13(6):620-21 (invited commentary) Pubmed abstract
| Skytthe A, Kyvik K, Holm NV, Vaupel JW, Christensen K. The Danish twin registry: 127 cohorts of twins. Twin Research, 2002;5(5):352-357.
| Kjeldsen MJ, Kyvik KO, Friis ML, Christensen K. Genetic and environmental factors in
febrile seizures: A Danish population-based twin study. Epilepsy Research 2002, 51:167-177.
Pubmed abstract
| Christensen K. Methodological issues in epidemiological studies of oral clefts. Cleft Lip and Palate - from origin to treatment: pp 101-107. Edited by Diego F. Wyszynski. Oxford University Press, 2002.
| Bak S, Sindrup SH, Alslev T, Kristensen O, Christensen K, Gaist D. Smoking cessation after first-ever stroke: A follow-up study. Stroke 2002, 33:2263-2269. Pubmed abstract
| Frederiksen H, Gaist D, Petersen HC, Hjelmborg J, McGue M, Vaupel JW, Christensen K. Hand Grip Strength - a phenotype suitable for identifying genetic variants affecting mid- and late- life physical functioning. Genetic Epidemiology 2002, 23:110-122. Pubmed abstract
| Tomassini C, Rosina A, Billari FC, Skytthe A, Christensen K. The effect of losing the partner and losing the twin on mortality. Twin Research 2002;5(3):210-217.
Pubmed abstract
| Iachina M, Jørgensen B, Christensen K, Iachine I. Analysis of functional abilities for elderly Danish twins using GEE models. Twin Research 2002,5(4):289-293.
| Christensen K, Mortensen PB. Facial clefting and psychiatric diseases: A follow-up of the Danish 1936-87 facial cleft cohort. Cleft Palate-Craniofacial Journal 2002;39(4):392-396.
Pubmed abstract
| Jensen TK, Carlsen E, Jørgensen N, Berthelsen JG, Keiding N, Christensen K, Petersen JH, Knudsen LB, Skakkebæk NE. Poor semen quality may contribute to recent decline in fertility rates. Human Reproduction 2002;17(6):1437-1440.
Pubmed abstract
| Petersen HC, Jeune B, Vaupel JW, Christensen K. Reproduction life history and hip fractures. Annals of Epidemiology 2002;12:257-263.
Pubmed abstract
| Tan Q, Yashin AI, Bladbjerg EM, de Maat MPM, Andersen-Ranberg K, Jeune B, Christensen K, Vaupel JW. A case-only approach for assessing gene by sex interaction in human longevity. Journal of Gerontology: Biological Sciences 2002;57A(4):B129-B133. Pubmed abstract
| Frederiksen H, McGue M, Jeune B, Gaist D, Nybo H, Skytthe A, Vaupel JW, Christensen K. Do children of long-lived parents age more successfully? Epidemiology 2002;13:334-339.
Pubmed abstract
| Andersen K, Nybo H, Gaist D, Petersen HC, McGue M, Jeune B, Vaupel JW, Christensen K. Cognitive impairment and mortality among nonagenarians: The Danish 1905 cohort survey. Dementia Geriatric Cognitive Disorders 2002;13(3):156-163.
Pubmed abstract
| Wienke A, Christensen K, Skytthe A, Yashin AI. Genetic analysis of cause of death in a mixture model of bivariate lifetime data. Statistical Modelling 2002;2:1-14.
| Bak S, Tsiropoulos I, Kjærsgaard JO, Andersen M, Mellerup E, Hallas J, Rodrígues LAG, Christensen K, Gaist D. Selective serotonin reuptake inhibitors and the risk of stroke: A population based case control study. Stroke 2002;33:1465-1473.
Pubmed abstract
| Bak S, Gaist D, Sindrup SH, Skytthe A, Christensen K. Genetic Liability in Stroke. A Long-Term Follow-Up Study of Danish Twins. Stroke 2002;33:769-774 Pubmed abstract
| Christensen K, Gaist D, Vaupel JW, McGue M. Genetic contribution to rate-of-change in functional abilities among Danish twins aged 75 years or more.
American Journal of Epidemiology 2002 Jan 15;155(2):132-139
Pubmed abstract
| 2001 .
| Tomassini C, Billari FC, Rosina A, Christensen K. Born together - die together. Live together - die together. The role of the partner and of the co-twin on
longevity at very old ages. Genus, 2001, Vol. LVII (3-4):63-82
| Christensen K, Frederiksen H, Hoffman HJ. Genetic and environmental influences on self-reported
hearing in the old and oldest old. Journal of the American
Geriatrics Society, 2001;49(11):1512-1517. Pubmed abstract
| McGue M, Christensen K. The heritability of cognitive functioning in very old adults: Evidence
from Danish twins aged 75 and older. Psychology and Aging
2001;16:272-280. Pubmed abstract
| Christensen K, Ørstavik K-H, Vaupel JW. “. The X Chromosome and the Female Survival Advantage: An Example of the Intersection between Genetics,
Epidemiology and Demography”. In: Population Health and
Aging: Strengthening the Dialogue Between Epidemiology and Demography, Annals of the New York Academy of Sciences, Volume
954, December 2001. Pubmed abstract
| Christensen K, Wienke A, Skytthe A, Holm NV, Vaupel JW, Yashin AI. Cardiovascular Mortality in Twins and the Fetal Origins Hypothesis. Twin Reseach 2001; 4:
344-349. Pubmed abstract
| Basso O, Christensen K, Olsen J. Higher risk of pre-eclampsia after change of partner. An effect of longer interpregnancy intervals? Epidemiology
2001;12:624-629 Pubmed abstract
| Bathum L, Christiansen L, Nybo H, Andersen-Ranberg K, Gaist D, Jeune B, Petersen NE, Vaupel JW, Christensen K. Association of mutations in the hemochromatosis gene
with shorter life expectancy. Archives of Internal Medicine
2001;16:2441-2444. Pubmed abstract
| Nybo H, Gaist D, Jeune B, McGue M, Vaupel JW, Christensen K. Functional status and self-rated health in 2,262 nonagenarians: the Danish 1905 Cohort Survey.
Journal of the American Geriatrics Society
2001;49(5):601-609. Pubmed abstract
| Rodgers JL, Hughes K, Kohler H-P, Christensen K, Doughty D, Rowe DC, Miller WB. Genetic influence helps explain variation in human fertility: Evidence from
recent behavioral and molecular genetic studies. Current
Directions in Psychology, 2001;10:184-188.
| Kjeldsen MJ, Kyvik KO, Christensen K, Friis ML. Genetic and environmental factors in epilepsy: A population-based study of 11,900 Danish twin pairs.
Epilepsy Research 2001;44:167-178.
Pubmed abstract
| Christensen K, Støvring H, McGue M. Do genetic factors contribute to the association between birth weight and blood pressure? Journal of
Epidemiology and Community Health 2001;55:583-587. Pubmed abstract
| Tan Q, Yashin AI, Bladbjerg EM, de Maat M, Andersen-Ranberg K, Jeune B, Christensen K, Vaupel JW. Variations of Cardiovascular Disease Associated Genes Exhibit Sex-dependent Influence on Human Longevity. Experimental
Gerontology 2001;36:1303-1315. Pubmed abstract
| Mitchell LE, Murray JC, O’Brien S, Christensen K. Evaluation of two putative susceptibility loci for oral clefts in the Danish population.
American Journal of Epidemiology
2001;153(10):1007-1015. Pubmed abstract
| De Benedictis G, Tan Q, Jeune B, Christensen K, Ukraintseva SV, Bonafe M, Franceschi C, Vaupel JW, Yashin AI. Recent advances in human gene-longevity association studies. Mechanisms of Ageing and Development
2001;122:909-920. Pubmed abstract
| Brix TH, Kyvik KO, Christensen K, Hegedüs L. Evidence for a major role of heredity in Graves' disease - a population based study of two Danish twin
cohorts. Journal of Clinical Endocrinology and Metabolism
2001;86(2):930-934. Pubmed abstract
| Nybo H, Gaist D, Jeune B, Bathum L, Vaupel JW, Christensen K. The Danish 1905-Cohort. A genetic-epidemiological nationwide survey. Journal of Aging and
Health 2001;13(1):32-46. Pubmed abstract
| Bathum L, Pedersen HC,Rosholm JU, Petersen PH, Vaupel JW, Christensen K. Evidence for a substantial genetic influence on biochemical liver function test:
results from a population based Danish twin study. Clinical
Chemistry 2001;47:81-87. Pubmed abstract
| Rodgers JL, Kohler H-P, Kyvik KO, Christensen K. Behavior genetic modeling of human fertility: Findings from a contemporary Danish twin study.
Demography 38(1); Feb 2001. Pubmed abstract
| 2000
Wienke A, Christensen K, Holm NV, Yashin AI. Heritability of death from respiratory diseases: An analysis of Danish twin survival data using a correlated frailty
model. In: Hasman et al. (eds) "Medial Infobahn for Europe".
Amsterdam, IOS Press 2000: pp. 407-411. Pubmed abstract
| Christensen K. Biological Material in Household Surveys. The Interface between Epidemiology and
Genetics. In National Research Council "Cells and Surveys. Should
Biological Measures Be Included in Social Science Research?"
Committee on Population; Finch CE, Vaupel JW and Kinsella K (eds.).
Commission on Behavioral and Social Sciences and Education.
Washington DC, National Academy Press 2000: 42-63.
[Download
here]
| Christensen K, McGue M, Yashin AI, Iachine IA, Holm NV, Vaupel JW. Genetic and Environmental Influences on Functional Abilities Among Danish Twins Aged 75 Years
and Older. Journal of Gerontology: Medical Sciences
2000;55A(8):M446-M452. Pubmed abstract
| Basso O, Olsen J, Holm NV, Skytthe A, Vaupel JW, Christensen K. Handedness and Mortality: A Follow-Up Study of Danish Twins Born between 1900 and 1910.
Epidemiology 2000; 11: 576-580. Pubmed abstract
| Kohler HP, Christensen K. Genetic influences on fertility behavior: Findings from a Danish twin
study. In: Rodgers JC, Rowe DC and Miller WB (eds.). "Genetic
Influences on Fertility and Sexuality". Kluwer Academic
Publishers 2000, pp. 67-84.
| Gaist D, Bathum L, Skytthe A, Jensen TK, McGue M, Vaupel JW, Christensen K. Strength and anthropometric measures in identical and fraternal twins: no evidence
of masculinization of females with male co-twins. Epidemiology
2000 May;11(3):340-3. Pubmed abstract
| Sørensen HT, Nielsen GL, Christensen K, Tage-Jensen U, Ekborn A, Baron J, Euromap Study Group. Birth outcome following maternal use of metoclopramide. J
Clin Pharmacol 2000;49:264-268. Pubmed abstract
| Christensen K, Kristiansen M, Hagen-Larsen H, Skytthe A, Bathum L, Jeune B, Andersen-Ranberg K,Vaupel JW, Ørstavik KH.. X-linked genetic factors regulate
hematopoietic stem-cell kinetics in females. Blood
2000;95:2449-2450.
Pubmed abstract
| Gaist D, Væth M, Tsiropoulos I, Christensen K, Coder E, Olsen J, Sørensen HT. The risk of subarachnoid haemorrhage in first degree relatives of
patients with subarachnoid haemorrhage: a follow-up study based on
national registries in Denmark. British Medical Journal
2000;320:141-145. Pubmed abstract
| 1999
Rufer N, Brümmendorf TH, Kolvraa S, Bischoff C, Christensen K, Wadsworth L, Schulzer M, Lansdorf PM. Telomere fluorescence measurements in granolocytes and T lymphocyte subsets indicate a high turnover of hematopoietic stem cells and memory T cells. Journal of Experimental Medicine
1999;190:157-167. Pubmed abstract
| Basso O, Olsen J, Christensen K. Recurrence risk of congenital anomalies: the impact of paternal, social and environmental factors.
A population-based study in Denmark. American Journal of Epidemiology
1999;150:598-604. Pubmed abstract
| Basso O, Olsen J, Christensen K. Low birthweight and prematurity in relation to paternal factors: a study of recurrence. International Journal of
Epidemiology 1999;28:695-700. Pubmed abstract
| Andersen-Ranberg K, Christensen K, Jeune B, Skytthe A, Vasegaard L, Vaupel JW. Activity of daily living among elderly and oldest-old in Denmark. Age and
Ageing 1999;28:373-377.
| Kohler HP, Rodgers JL,Christensen K. Is fertility behaviour in our genes? Findings from a
Danish twin study. Population and Development Review
1999;25:253-288.
| Christensen K. Hvorfor ældes vi forskelligt? [Why do we age differently?] Copenhagen: Gyldendal, 2000.
| Christensen K. The 20th Century Danish Facial Cleft Population - Epidemiological and
Genetic-Epidemiological Studies. Cleft Palate-Craniofacial
Journal 1999;36:96-104. Pubmed abstract
| Christensen K, Olsen J, Nørgaard-Pedersen B, Basso O, Støvring H, Milhollin-Johnson L, Murray JC. Oral clefts,transforming-growth-factor-alpha gene variants, and maternal smoking.
A population based case-control study in Denmark 1991-1994.
American Journal of Epidemiology 1999;149:248-255. Pubmed abstract
| Olsen J., Basso O., Christensen K. Male factors and socioeconomic indicators correlate
with the risk of spontaneous abortion. Journal of Obstetrics and
Gynaecology 1999; 19:49-53.
| Skadhauge L.R., Christensen K., Kyvik K.C., Sigsgaard T. Genetic and environmental influence on
astma. A population-based study of 11,688 Danish twin pairs.
European Journal of Lung Medicine 1999;13:8-14. (Accompanied
by editorial 2-4). Pubmed abstract
| Basso O, Olsen J, Christensen K. A study of environmental, social and paternal factors
in preterm delivery using sibs and half sibs. A population-based
study in Denmark. Journal of Epidemiology and Community Health
1999;53:20-23. Pubmed abstract
| Christensen K, Holm NV, McGue M, Corder L, Vaupel JW. A Danish population- based twin study
on general health in the elderly. Journal of Aging and Health
1999;11:49-64. Pubmed abstract
| 1998
Basso O, Olsen J, Christensen K. Risk of preterm delivery, low birthweight and growth
retardation following spontaneous abortion. A registry-based study in
Denmark. International Journal of Epidemiology
1998;27:642-646. Pubmed abstract
| Christensen K, Gaist D, Jeune B, Vaupel JW. A tooth per child? Lancet
1998;352:204. Pubmed abstract
| Yashin AI, Iachine IA, Christensen K, Holm NV, Vaupel JW. Genetic component of discrete disability traits: liability models with age dependent thresholds.
Behaviour Genetics 1998;28:207-214. Pubmed abstract
| Vaupel JW., J. Carey, Christensen K, T. Johnson, A.I. Yashin, N.V. Holm, I.A. Iachine, V. Kannisto, A. Khazaeli, P. Liedo, V. Longo, Z. Yi, K. Manton, J. Curtsinger. Biodemographic trajectories of longevity. Science
1998; 280: 855-60. Pubmed abstract
| Christensen K, Vaupel JW. Prenatal exposure to famine and later life health. Lancet
1998;351:1361. Pubmed abstract
| Brix T.H., Christensen K, N.V. Holm, B. Harvald, L. Hegedüs. A population based study of Graves' disease in Danish twins. Clinical Endocrinology 1998;
48: 397-400. Pubmed abstract
| Basso O., J. Olsen, L. B. Knudsen, Christensen K. Low birthweight and preterm birth following
short interpregnancy interval. American Journal of Obstetrics and
Gynecology 1998; 178: 259-63. Pubmed abstract
| Christensen K, O. Basso,K.O. Kyvik, S. Juul, J, Boldsen, Vaupel JW. J. Olsen. Fecundability of female twins. Epidemiology 1998; 9: 189-192. Pubmed abstract
| Før 1998 .
| Basso O, Olsen J, Johansen AMT, Christensen K. Downward social mobility is an important
determinant of low birth weight. British Medical Journal
1997:315:1498-1502.
| Kannisto V, Christensen K,Vaupel JW. No increased mortality in later life for cohorts born
during famine. American Journal of Epidemiology
1997:145:987-94. Pubmed abstract
| Christensen K, Vaupel JW. Determinants of longevity: Genetic, environmental and medical factors
[Solicited review]. Journal of Internal Medicine
1996:240:333-341.
Pubmed abstract
| Christensen K, Holm NV,Vaupel J. Alzheimers disease and twins. Lancet 1996:347:976. Pubmed abstract
| Christensen K, Schmidt MM,Væth M, Olsen J. Absence of an environmental effect on the
recurrence of facial-cleft defects. New England Journal of
Medicine 1995:333:161-164. Pubmed abstract
| Christensen K, Vaupel J, Holm NV, Yashin AI. Mortality among twins after age 6: fetal origins hypothesis versus twin method. British Medical Journal 1995:310:432-436. Pubmed abstract
|
|
![](grafik/Topblaa.gif"){kind=small}
